L-NOARG, an inhibitor of nitric oxide synthase, induces catalepsy in mice

Neuroreport. 1995 Dec 29;7(1):158-60.

Abstract

The objective of this study was to investigate possible motor effects of NG-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase. Acute administration of L-NOARG (5-80 mg kg-1, i.p.) induced catalepsy in a dose-dependent manner in male albino-Swiss mice. The drug had an additive effect with haloperidol (0.125-0.5 mg kg-1, i.p.). The acute effect of L-NOARG (40 mg kg-1, i.p.) was attenuated by previous treatment with L-arginine (300 mg kg-1, i.p.). Sub-chronic treatment with L-NOARG (40 mg kg-1, i.p., twice a day for 4 days) was also able to attenuate the cataleptic effect of acute drug administration (40 mg kg-1, i.p.). These results show that acute systemic injections of L-NOARG induce significant motor effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Arginine / analogs & derivatives*
  • Arginine / toxicity
  • Catalepsy / chemically induced*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / toxicity*
  • Male
  • Mice
  • Motor Activity / drug effects*
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitroarginine

Substances

  • Enzyme Inhibitors
  • Nitroarginine
  • Arginine
  • Nitric Oxide Synthase