Abstract
1. We investigated the effects of cigarette smoke-modified low-density lipoprotein (CS-LDL) on endothelium-dependent relaxations in various isolated rabbit arteries, and compared them with those of oxidized LDL (Ox-LDL). 2. In aorta rings, acetylcholine-induced endothelium-dependent relaxations were attenuated by preincubation with CS-LDL and Ox-LDL. Endothelium-independent relaxations induced by sodium nitroprusside were not modified. Similar changes were observed in rings of coronary and basilar arteries. 3. These findings indicate that CS-LDL, as well as Ox-LDL, may decrease the release or activity of endothelium-derived relaxing factor in vascular endothelial cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylcholine / metabolism
-
Animals
-
Electrophoresis, Agar Gel
-
Endothelium, Vascular / physiology*
-
In Vitro Techniques
-
Lipoproteins, LDL / blood
-
Lipoproteins, LDL / chemistry
-
Lipoproteins, LDL / pharmacology*
-
Muscle Relaxation / drug effects
-
Muscle, Smooth, Vascular / drug effects*
-
Muscle, Smooth, Vascular / metabolism
-
Muscle, Smooth, Vascular / physiology
-
Nitric Oxide / metabolism
-
Nitroprusside / pharmacology
-
Oxidation-Reduction
-
Rabbits
-
Smoking / blood*
-
Thiobarbituric Acid Reactive Substances / chemistry
-
Vasodilator Agents / pharmacology
Substances
-
Lipoproteins, LDL
-
Thiobarbituric Acid Reactive Substances
-
Vasodilator Agents
-
Nitroprusside
-
Nitric Oxide
-
Acetylcholine