Aclacinomycin X, a novel anthracycline antibiotic produced by Streptomyces galilaeus ATCC 31133

Biosci Biotechnol Biochem. 1996 May;60(5):906-8. doi: 10.1271/bbb.60.906.

Abstract

A new anthracycline antibiotic, designated as aclacinomycin X, was isolated from the culture broth of Streptomyces galilaeus ATCC 31133, and was identified as 7-(O-rhodosaminyl-deoxyfucosyl-rednosyl)- aklavinone. Its in vitro cytotoxicity was tested against several human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aclarubicin / analogs & derivatives*
  • Aclarubicin / biosynthesis
  • Aclarubicin / chemistry
  • Aclarubicin / isolation & purification
  • Aclarubicin / metabolism
  • Aclarubicin / toxicity
  • Adjuvants, Immunologic / biosynthesis
  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / isolation & purification*
  • Adjuvants, Immunologic / toxicity
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / toxicity
  • Cell Division / drug effects
  • Culture Media
  • Humans
  • Leukemia / pathology
  • Magnetic Resonance Spectroscopy
  • Melanoma / pathology
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured

Substances

  • 11-hydroxyaclacinomycin X
  • Adjuvants, Immunologic
  • Antibiotics, Antineoplastic
  • Culture Media
  • aclacinomycins
  • Aclarubicin