The shear bond strength between fresh amalgam and composite resin using three adhesive systems was assessed. Amalgambond (5.19 MPa), All-Bond (3.45 MPa), and Clearfil New-Bond (4.37 MPa) had comparable shear bond strengths higher than Enamel Bond (1.27 MPa) after 48 hours of water immersion. This bond was hydrolytically degraded during 100 days of immersion in water. The greatest deterioration was observed for Clearfil New-Bond (0.81 MPa). Amalgambond provided the best results, whereas All-Bond and Clearfil New-Bond had comparable bond strength to Enamel Bond at the end of the experiment.