A new cytotoxic cholestane bisdesmoside from Ornithogalum saundersiae bulbs

Biosci Biotechnol Biochem. 1996 Jun;60(6):1049-50. doi: 10.1271/bbb.60.1049.

Abstract

Bioassay-guided fractionation of the MeOH extract of Ornithogalum saundersiae bulbs led to the isolation of a new cholestane bisdesmoside with potent cytotoxic activities toward leukemia HL-60 and MOLT-4 cells. The structure was deduced mainly from spectroscopic information.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Cholestanes / chemistry
  • Cholestanes / isolation & purification*
  • Cholestanes / pharmacology
  • Drug Screening Assays, Antitumor
  • Gallic Acid / analogs & derivatives
  • Gallic Acid / chemistry
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Plants / chemistry
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Cholestanes
  • Gallic Acid
  • 3,4,5-trimethoxybenzoic acid