Boromycin, an anti-HIV antibiotic

Biosci Biotechnol Biochem. 1996 Jun;60(6):1036-7. doi: 10.1271/bbb.60.1036.

Abstract

The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Deoxynojirimycin / analogs & derivatives
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Borates / chemistry
  • Borates / pharmacology*
  • Cell Line
  • Dextran Sulfate / pharmacology
  • Glucosamine / analogs & derivatives
  • Glucosamine / pharmacology
  • Glycoside Hydrolases / antagonists & inhibitors
  • HIV Reverse Transcriptase
  • HIV-1 / drug effects*
  • HIV-2 / drug effects*
  • Humans
  • Molecular Structure
  • RNA-Directed DNA Polymerase / drug effects
  • RNA-Directed DNA Polymerase / metabolism
  • Streptomyces / metabolism

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • Borates
  • 1-Deoxynojirimycin
  • boromycin
  • Dextran Sulfate
  • HIV Reverse Transcriptase
  • RNA-Directed DNA Polymerase
  • Glycoside Hydrolases
  • Glucosamine
  • nojirimycin