Abstract
The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Deoxynojirimycin / analogs & derivatives
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Borates / chemistry
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Borates / pharmacology*
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Cell Line
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Dextran Sulfate / pharmacology
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Glucosamine / analogs & derivatives
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Glucosamine / pharmacology
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Glycoside Hydrolases / antagonists & inhibitors
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HIV Reverse Transcriptase
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HIV-1 / drug effects*
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HIV-2 / drug effects*
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Humans
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Molecular Structure
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RNA-Directed DNA Polymerase / drug effects
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RNA-Directed DNA Polymerase / metabolism
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Streptomyces / metabolism
Substances
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Anti-Bacterial Agents
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Antiviral Agents
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Borates
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1-Deoxynojirimycin
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boromycin
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Dextran Sulfate
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HIV Reverse Transcriptase
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RNA-Directed DNA Polymerase
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Glycoside Hydrolases
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Glucosamine
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nojirimycin