Two new taxoids from the stem bark of Taxus baccata

Y Guo; B Diallo; M Jaziri; R Vanhaelen-Fastré; M Vanhaelen; R Ottinger

doi:10.1021/np50126a017

Two new taxoids from the stem bark of Taxus baccata

J Nat Prod. 1995 Dec;58(12):1906-12. doi: 10.1021/np50126a017.

Authors

Y Guo¹, B Diallo, M Jaziri, R Vanhaelen-Fastré, M Vanhaelen, R Ottinger

Affiliation

¹ Pharmaceutical Institute, Université Libre de Bruxelles, Belgium.

PMID: 8691211
DOI: 10.1021/np50126a017

Abstract

Two new taxoids, 13-deoxo-13 alpha-acetyloxy-7 beta,9 alpha-diacetyl-1,2-dideoxytaxine B[1] and 7 beta-xylosyl-10-deacetyltaxol D [7], were isolated from the stem bark of Taxus baccata cv. stricta. Their structures were elucidated using spectroscopic methods and their bioactivity was evaluated using an in vitro microtubule assembly assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Chemistry / drug effects
Kinetics
Magnetic Resonance Spectroscopy
Microtubules / drug effects
Microtubules / metabolism
Paclitaxel / analogs & derivatives*
Paclitaxel / chemistry
Paclitaxel / pharmacology
Plant Stems / chemistry*
Plants, Medicinal / chemistry*
Swine
Taxoids*
Tubulin / biosynthesis

Substances

13-deoxo-13-acetyloxy-7,9-diacetyl-1,2-dideoxytaxine
7-xylosyl-10-deacetyltaxol
Taxoids
Tubulin
Paclitaxel