Therapies aimed at salvaging jeopardized myocardium in patients with acute myocardial infarction (MI) are now routine. The success of these therapies must often be estimated by non-invasive tests, such as the 12-lead electrocardiogram (ECG) or two-dimensional echocardiography. To monitor QRS changes and left ventricular (LV) function over time in patients who have received therapies aimed at myocardial salvage, it is important to know the 'spontaneous' evolution of these estimates. Consecutive MI survivors admitted in the pre-thrombolytic era with their first MI were re-studied at 4 years. Patients were excluded if they had experienced reinfarction, coronary revascularization or bundle branch block in the acute or follow-up period. A standard ECG and a two-dimensional echocardiogram were obtained prior to discharge and at follow-up. The quantitative ECG analysis was performed according to the Selvester QRS scoring method. During the two-dimensional echocardiogram each of the 20 segments of the LV were assessed to provide a wall motion score. Eighty patients with a median age of 64 years (range 40-79) were included in the study. Thirty-two had anterior and 48 inferior MI. A significant decrement in median QRS score-estimated AMI size occurred between pre-discharge and follow-up ECGs in the entire group (18.3% vs 10.5%; P<0.0001). This difference occurred in both anterior (21.6% vs 10.5%; P<0.0001) and inferior-posterior (16.5 vs 10.5%; P<0.0001) MI locations. In the anterior MI group ther was a trend towards a greater total decrease of QRS points than in the inferior-posterior MI group (42% vs 27%; P=0.10). Within the anterior MI group, more QRS points awarded in the anteroseptal leads (V1-V3) remained follow-up than in the anterosuperior and apical leads (I, aVL and V4-V6), (80% vs 49%; P=0,03).