Abstract
The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
MeSH terms
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Animals
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Antigens, CD / biosynthesis
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Antigens, CD / genetics
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Antigens, CD19 / biosynthesis
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Antigens, CD19 / genetics
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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B-Lymphocytes / physiology*
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Base Sequence
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Binding Sites
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Cell Differentiation
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Conserved Sequence
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DNA-Binding Proteins / biosynthesis
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DNA-Binding Proteins / metabolism*
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Gene Expression
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Gene Rearrangement
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Genes, Immunoglobulin
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Humans
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Immunoglobulin Heavy Chains / genetics
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Mice
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Molecular Sequence Data
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Nuclear Proteins / biosynthesis
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Nuclear Proteins / metabolism*
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PAX5 Transcription Factor
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Receptors, Fc / biosynthesis
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Receptors, Fc / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic
Substances
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Antigens, CD
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Antigens, CD19
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DNA-Binding Proteins
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Immunoglobulin Heavy Chains
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Nuclear Proteins
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PAX5 Transcription Factor
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PAX5 protein, human
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Pax5 protein, mouse
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Receptors, Fc
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Transcription Factors
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immunoglobulin M receptor