The role of BSAP (Pax-5) in B-cell development

Curr Opin Genet Dev. 1995 Oct;5(5):595-601. doi: 10.1016/0959-437x(95)80028-x.

Abstract

The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis
  • Antigens, CD / genetics
  • Antigens, CD19 / biosynthesis
  • Antigens, CD19 / genetics
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / physiology*
  • Base Sequence
  • Binding Sites
  • Cell Differentiation
  • Conserved Sequence
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / metabolism*
  • Gene Expression
  • Gene Rearrangement
  • Genes, Immunoglobulin
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / biosynthesis
  • Nuclear Proteins / metabolism*
  • PAX5 Transcription Factor
  • Receptors, Fc / biosynthesis
  • Receptors, Fc / genetics
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • Antigens, CD
  • Antigens, CD19
  • DNA-Binding Proteins
  • Immunoglobulin Heavy Chains
  • Nuclear Proteins
  • PAX5 Transcription Factor
  • PAX5 protein, human
  • Pax5 protein, mouse
  • Receptors, Fc
  • Transcription Factors
  • immunoglobulin M receptor