A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23

Genomics. 1996 Apr 15;33(2):199-206. doi: 10.1006/geno.1996.0184.

Abstract

A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ataxia Telangiectasia / genetics
  • Base Sequence
  • Cell Line
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 9
  • Cricetinae
  • DNA, Complementary
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Pseudogenes
  • RNA Helicases
  • RNA Nucleotidyltransferases / genetics*
  • Sequence Homology, Amino Acid
  • Trinucleotide Repeats

Substances

  • DNA, Complementary
  • RNA Nucleotidyltransferases
  • RNA Helicases

Associated data

  • GENBANK/U28042