Inhibitory effects of some steroidal saponins on human spermatozoa in vitro

Y F Wang; X C Li; H Y Yang; J J Wang; C R Yang

doi:10.1055/s-2006-957834

Inhibitory effects of some steroidal saponins on human spermatozoa in vitro

Planta Med. 1996 Apr;62(2):130-2. doi: 10.1055/s-2006-957834.

Authors

Y F Wang¹, X C Li, H Y Yang, J J Wang, C R Yang

Affiliation

¹ Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.

PMID: 8657744
DOI: 10.1055/s-2006-957834

Abstract

Twenty-nine C-27 steroidal saponins were tested for the inhibitory effects on human spermatozoa in vitro by means of a modified Sander-Cramer method. Twelve of them are responsible for this activity. The structure-activity relationship is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Male
Plants*
Saponins / chemistry
Saponins / isolation & purification
Saponins / pharmacology*
Sperm Motility / drug effects
Spermatozoa / drug effects*
Spermatozoa / physiology
Steroids / chemistry
Steroids / isolation & purification
Steroids / pharmacology*
Structure-Activity Relationship

Substances

Saponins
Steroids