A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones

Leukemia. 1996 May;10(5):909-17.
No abstract available

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carrier Proteins / genetics*
  • Cell Cycle Proteins*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 9 / genetics
  • Chromosomes, Human, Pair 9 / ultrastructure*
  • Cyclin-Dependent Kinase Inhibitor p15
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Dexamethasone / administration & dosage
  • Doxorubicin / administration & dosage
  • Drug Resistance, Neoplasm
  • Etoposide / administration & dosage
  • Fatal Outcome
  • Gene Deletion*
  • Humans
  • Immunologic Factors / therapeutic use*
  • Interferon-alpha / therapeutic use*
  • Male
  • Neoplasm Proteins / deficiency
  • Neoplasm Proteins / genetics*
  • Neoplastic Stem Cells / pathology*
  • Polymerase Chain Reaction
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Prednisone / administration & dosage
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Salvage Therapy
  • Tumor Suppressor Proteins*
  • Vincristine / administration & dosage

Substances

  • CDKN2B protein, human
  • Carrier Proteins
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p15
  • Cyclin-Dependent Kinase Inhibitor p16
  • Immunologic Factors
  • Interferon-alpha
  • Neoplasm Proteins
  • RNA, Messenger
  • RNA, Neoplasm
  • Tumor Suppressor Proteins
  • Cytarabine
  • Vincristine
  • Etoposide
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
  • Daunorubicin

Supplementary concepts

  • EPOCH protocol