On the structure of replication and transcription factories

T A Hughes; A Pombo; J McManus; P Hozák; D A Jackson; P R Cook

doi:10.1242/jcs.1995.supplement_19.8

On the structure of replication and transcription factories

J Cell Sci Suppl. 1995:19:59-65. doi: 10.1242/jcs.1995.supplement_19.8.

Authors

T A Hughes¹, A Pombo, J McManus, P Hozák, D A Jackson, P R Cook

Affiliation

¹ CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK.

PMID: 8655648
DOI: 10.1242/jcs.1995.supplement_19.8

Abstract

Recent experiments suggest that active polymerases are concentrated in large structures, 'factories', within eukaryotic nuclei. Data concerning the structure of these factories is reviewed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Nucleus / enzymology
Cell Nucleus / ultrastructure*
DNA Replication*
DNA-Directed DNA Polymerase / analysis
DNA-Directed RNA Polymerases / analysis
Humans
Models, Genetic
Transcription, Genetic*

Substances

DNA-Directed RNA Polymerases
DNA-Directed DNA Polymerase

Grants and funding

Wellcome Trust/United Kingdom