Inactivated bovine herpesvirus 1 induces apoptotic cell death of mitogen-stimulated bovine peripheral blood mononuclear cells

J Virol. 1996 Jun;70(6):4116-20. doi: 10.1128/JVI.70.6.4116-4120.1996.

Abstract

Bovine herpesvirus 1 (BHV-1) is able to inhibit the proliferation of bovine peripheral blood mononuclear cells. Here, we have demonstrated that live BHV-1 and, interestingly, inactivated BHV-1 can induce apoptosis of mitogen-stimulated bovine peripheral blood mononuclear cells in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • Cattle
  • Cells, Cultured
  • DNA / metabolism
  • Herpesvirus 1, Bovine / physiology*
  • Ionomycin / pharmacology
  • Leukocytes, Mononuclear / pathology*
  • Phorbol 12,13-Dibutyrate / pharmacology
  • Viral Proteins / analysis

Substances

  • Viral Proteins
  • Phorbol 12,13-Dibutyrate
  • Ionomycin
  • DNA