Effects of calmodulin antisense oligonucleotides on chemoresponse in Paramecium

J Yano; D Fraga; R Hinrichsen; J L Van Houten

doi:10.1093/chemse/21.1.55

Effects of calmodulin antisense oligonucleotides on chemoresponse in Paramecium

Chem Senses. 1996 Feb;21(1):55-8. doi: 10.1093/chemse/21.1.55.

Authors

J Yano¹, D Fraga, R Hinrichsen, J L Van Houten

Affiliation

¹ University of Vermont, Department of Biology, Burlington 04505, USA.

PMID: 8646492
DOI: 10.1093/chemse/21.1.55

Abstract

The calcium/calmodulin-regulated Ca-ATPase of the plasma membrane is implicated in Paramecium chemosensory transduction. Calmodulin antisense oligonucleotides electroporated into Paramecium disrupt chemosensory responses to sodium acetate but not to ammonium chloride.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acetates / pharmacology
Acetic Acid
Ammonium Chloride / pharmacology
Animals
Behavior, Animal / drug effects*
Calcium-Transporting ATPases / antagonists & inhibitors
Calcium-Transporting ATPases / physiology
Calmodulin / genetics*
Oligonucleotides, Antisense / pharmacology*
Paramecium / drug effects*
Paramecium / physiology

Substances

Acetates
Calmodulin
Oligonucleotides, Antisense
Ammonium Chloride
Calcium-Transporting ATPases
Acetic Acid