Prospective clinical study included the group of 44 patients who had the acute phase of poststreptococcal glomerulonephritis (PSGN) between the age of 18 and 22 during their military service. After the acute phase the patients were followed up to 5 years in order to investigate the influence of some clinical and laboratory parameters in the acute phase of PSGN on the evolution of this disease. The evolution of the disease, estimated on the basis of pathological findings in urine (proteinuria and erhytrocyturia), was found in 61% of patients. It was shown that severity of the clinical picture and the degree of proteinuria in the acute phase of PSGN were in direct correlation with the evolution of disease. On the other hand, the elevated concentrations of circulatory immune complexes (CIC) and cryoglobulin in the acute phase did not significantly affect the evolution of the disease although in some degree it contributed to the severity of pathological findings in the urine.