Abstract
Genome sequencing is leading to the discovery of new genes at a rate 50-100 times greater than that achieved by classical genetics, but the biological function of almost half of these genes is completely unknown. In order fully to exploit genome sequence data, a systematic approach to the discovery of gene function is required. Possible strategies are discussed here in the context of functional analysis in the yeast Saccharomyces cerevisiae, a model eukaryote whose genome sequence will soon be completed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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DNA, Fungal
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Genes, Fungal / physiology*
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Genome
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Humans
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Molecular Sequence Data
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Open Reading Frames
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Phenotype
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Saccharomyces cerevisiae / genetics*
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Sequence Homology, Nucleic Acid
Associated data
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GENBANK/L11353
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GENBANK/L12392
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GENBANK/L13923
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GENBANK/M88162
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GENBANK/M97252
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GENBANK/S65791
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GENBANK/U18796
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GENBANK/U40990
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GENBANK/U43491
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GENBANK/U43746
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GENBANK/X59720
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GENBANK/X65882
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GENBANK/X75621
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GENBANK/X82086
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GENBANK/X82434
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GENBANK/X83121
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GENBANK/X85811
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GENBANK/Z28082
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GENBANK/Z35807
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GENBANK/Z36104
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GENBANK/Z47047