Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro

J Med Chem. 1996 Apr 26;39(9):1757-9. doi: 10.1021/jm950836q.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Drug Design
  • HIV / drug effects*
  • Hepatitis B virus / drug effects*
  • Humans
  • Zalcitabine / analogs & derivatives*
  • Zalcitabine / chemical synthesis
  • Zalcitabine / pharmacology

Substances

  • Antiviral Agents
  • Zalcitabine
  • 2',3'-dideoxycytidinene
  • dexelvucitabine