Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines

K Beyreuther; G Multhaup; U Mönning; R Sandbrink; D Beher; L Hesse; D H Small; C L Masters

doi:10.1111/j.1749-6632.1996.tb34403.x

Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines

Ann N Y Acad Sci. 1996 Jan 17:777:74-6. doi: 10.1111/j.1749-6632.1996.tb34403.x.

Authors

K Beyreuther¹, G Multhaup, U Mönning, R Sandbrink, D Beher, L Hesse, D H Small, C L Masters

Affiliation

¹ ZMBH, Center for Molecular Biology, University of Heidelberg, Germany. bsa784@sun0.urz.uni-heidelberg.de

PMID: 8624129
DOI: 10.1111/j.1749-6632.1996.tb34403.x

Abstract

We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amyloid beta-Protein Precursor / metabolism*
Cytokines / physiology*
Extracellular Matrix / physiology*
Humans

Substances

Amyloid beta-Protein Precursor
Cytokines