Abstract
We report on two girls, 3 and 13 years old, with acute promyelocytic leukemia (APL) who were successfully treated with all-trans retinoic acid (ATRA) 45 mg/m2/day. "Retinoic acid syndrome" was prevented with short-time treatment of high dose (4 x 1.5 g/m2) cytarabine. This regimen was well tolerated, although both children were critically ill. They achieved a complete remission confirmed by light microscopy, but reverse transcriptase polymerase chain reaction remained positive after ATRA, underlining the need of further chemotherapy.
MeSH terms
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Adolescent
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / therapeutic use*
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use*
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Child, Preschool
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Critical Illness
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Cytarabine / administration & dosage
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Cytarabine / therapeutic use*
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Female
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Humans
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Leukemia, Promyelocytic, Acute / drug therapy*
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Leukocytosis / chemically induced
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Leukocytosis / drug therapy
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Remission Induction
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Syndrome
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Tretinoin / administration & dosage
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Tretinoin / adverse effects
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Tretinoin / therapeutic use*
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Cytarabine
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Tretinoin