Nondysplastic fetal renal hypoplasia associated with severe oligohydramnios: clinical, pathologic, and morphometric findings

Pediatr Pathol Lab Med. 1995 May-Jun;15(3):485-501. doi: 10.3109/15513819509026985.

Abstract

Two fetuses with severe bilateral renal hypoplasia are described; both diagnoses were made following elective abortion for oligohydramnios and suspected renal dysplasia. A 20-week female fetus (46,XX) had pulmonary hypoplasia and very small kidneys (7% of expected weight) that were normally shaped and nondysplastic, with well-formed medullae and metanephric blastema and markedly diminished cortices with only rare glomeruli. A 23-week male fetus (46,XY) had small kidneys (13% of expected weight) that were nondysplastic, normally shaped, and histologically well organized with moderately decreased numbers of glomeruli. Isolated bilateral renal hypoplasia has not previously been well characterized in fetuses; the presence of oligohydramnios (both cases) and pulmonary hypoplasia (one case) suggests that this finding is associated with impaired fetal renal function and may adversely influence neonatal survival.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Fetal Death / etiology
  • Humans
  • Kidney / abnormalities*
  • Kidney / pathology*
  • Male
  • Oligohydramnios / complications
  • Oligohydramnios / pathology*