IR and turbidity studies of vitamin E-cholesterol-phospholipid membrane interactions

Biosci Rep. 1995 Aug;15(4):221-9. doi: 10.1007/BF01540456.

Abstract

Binary and tertiary mixture of alpha-tocophenol, cholesterol and dimyristoylphosphatidylcholine in the form of multilamellar liposomes were investigated by Fourier Transform Infrared and visible spectroscopy. Results of the FTIR and turbidity experiments indicate that alpha T decreases or diminishes the effect of cholesterol on the frequency and the bandwidth of the C-H stretching, CH2 scissoring and C = O stretching bands in FTIR spectra and the turbidity measurements (recorded as absorbance values at 440 nm) in phospholipid model membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / metabolism
  • Cholesterol / pharmacology*
  • Dimyristoylphosphatidylcholine / metabolism
  • Drug Interactions
  • Liposomes / metabolism
  • Membrane Lipids / pharmacology*
  • Nephelometry and Turbidimetry
  • Phospholipids / metabolism
  • Spectroscopy, Fourier Transform Infrared
  • Vitamin E / pharmacology*

Substances

  • Liposomes
  • Membrane Lipids
  • Phospholipids
  • Vitamin E
  • Cholesterol
  • Dimyristoylphosphatidylcholine