Autism is a psychopathological disorder of childhood characterized by severe lapses in behaviour and cognition and excessive presence of extravagant unsuitable behaviour that affects a child's development. It is associated with different conditions of the Central Nervous System, especially a high incidence of epilepsy. We report a case of autistic syndrome with refractory temporal epilepsy, describing its clinical onset, (type of seizures, focal anomalies on the EEG, evidence of relation between limbic disfunction and autism.