Mortality rate caused by esophageal cancer in Belgrade 1975-1989 was presented. During this fifteen-year period the average standardized mortality rate for esophageal cancer was 1.7 per 100,000 inhabitants. It was more than three times higher in males than in females (2.8:100,000 and 0.8:100,000). Mortality rates were age dependent and they were particularly higher in males over 45, so that the highest values were recorded in the oldest age group. Mortality rate for esophageal cancer during the period 1975-1989 was mildly ascending (y = 1.39 + 0.04x). According to the standard mortality rate its value for esophageal cancer in Belgrade was within the frame of a low risk of dying due to this localization of digestive tract malignant neoplasms.