A novel TaqI/DQA RFLP associated with HLA-DR9, DQ9 (DQA1*0302)

Eur J Immunogenet. 1995 Jun;22(3):261-4. doi: 10.1111/j.1744-313x.1995.tb00240.x.

Abstract

A new TaqI/DQA restriction fragment length polymorphism (RFLP) has been found in two Spanish Caucasoid individuals. The novel polymorphic fragment has a relative mobility of 4.2 kb and is associated with an HLA-A2,Cw*1401,B51,DR9,DR53,DQ9 haplotype. Nucleotide sequence analysis indicates that individuals showing this RFLP pattern do not carry a new DQA1 allele, but that (DQA1*0302) commonly observed in DR9,DQ9 haplotypes. The new RFLP seems to be a locally restricted marker of uncertain origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • Deoxyribonucleases, Type II Site-Specific*
  • Female
  • HLA-DQ Antigens / genetics*
  • HLA-DQ alpha-Chains
  • HLA-DR Antigens / genetics*
  • HLA-DR Serological Subtypes
  • Haplotypes / genetics
  • Humans
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Polymorphism, Restriction Fragment Length*
  • Spain
  • White People / genetics

Substances

  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen
  • HLA-DR Antigens
  • HLA-DR Serological Subtypes
  • HLA-DR9 antigen
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases