Identification of N4-(2-propenal)spermidine as a major reaction product of malondialdehyde and spermidine

M Niitsu; T Ohya; X S Xu; K Samejima

doi:10.1248/bpb.18.1162

Identification of N4-(2-propenal)spermidine as a major reaction product of malondialdehyde and spermidine

Biol Pharm Bull. 1995 Aug;18(8):1162-4. doi: 10.1248/bpb.18.1162.

Authors

M Niitsu¹, T Ohya, X S Xu, K Samejima

Affiliation

¹ Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

PMID: 8535418
DOI: 10.1248/bpb.18.1162

Abstract

The reactivity of malondialdehyde(MDA) with spermidine at the physiological pH was considerably higher than that with putrescine, glycine, lysine, methylamine or dimethylamine, and the major reaction product of MDA-spermidine adduct was identified as N4-(2-propenal)spermidine.

MeSH terms

Chromatography, High Pressure Liquid
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Malondialdehyde / chemistry*
Spectrophotometry, Ultraviolet
Spermidine / analogs & derivatives*
Spermidine / chemistry*

Substances

N(4)-(2-propenal)spermidine
Malondialdehyde
Spermidine