Cytotoxic ent-kaurene diterpenoids from Isodon gesneroides

Phytochemistry. 1995 Nov;40(5):1461-7. doi: 10.1016/0031-9422(95)00373-f.

Abstract

From Isodon gesneroides, three new cytotoxic diterpenoids, gesneroidins A, B and C, together with one known diterpenoid, dawoensin A, were isolated, and the structure determination and unambiguous assignment of their stereochemistry and NMR spectral data were made by a combination of one-and two-dimensional NMR techniques, computer modelling calculations and X-ray analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / toxicity
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / toxicity
  • Computer Simulation
  • Crystallography, X-Ray
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / toxicity
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Stereoisomerism

Substances

  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Diterpenes