Non specific resistance against malaria pre-erythrocytic stages: involvement of acute phase proteins

Parasite. 1995 Sep;2(3):263-8. doi: 10.1051/parasite/1995023263.

Abstract

Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of alpha-1 antitrypsin, alpha-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Proteins / analysis
  • Acute-Phase Proteins / immunology*
  • Adolescent
  • Adult
  • Animals
  • Antibodies, Protozoan / analysis
  • Cells, Cultured
  • Female
  • Humans
  • Immunity, Innate
  • Liver / parasitology
  • Liver / pathology
  • Malaria / epidemiology
  • Malaria / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium falciparum / immunology
  • Plasmodium yoelii / immunology
  • Thailand / epidemiology

Substances

  • Acute-Phase Proteins
  • Antibodies, Protozoan