Abstract
Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of alpha-1 antitrypsin, alpha-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute-Phase Proteins / analysis
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Acute-Phase Proteins / immunology*
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Adolescent
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Adult
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Animals
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Antibodies, Protozoan / analysis
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Cells, Cultured
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Female
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Humans
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Immunity, Innate
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Liver / parasitology
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Liver / pathology
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Malaria / epidemiology
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Malaria / immunology*
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Mice
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Mice, Inbred BALB C
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Plasmodium falciparum / immunology
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Plasmodium yoelii / immunology
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Thailand / epidemiology
Substances
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Acute-Phase Proteins
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Antibodies, Protozoan