Abstract
CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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CD4 Antigens / analysis
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CD8 Antigens / analysis*
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Cell Line
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Cells, Cultured
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Cytotoxicity, Immunologic
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Immunophenotyping
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Interleukin-10 / biosynthesis
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Interleukin-2 / pharmacology
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Interleukin-4 / biosynthesis
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Interleukin-4 / pharmacology
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Interleukin-5 / biosynthesis
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Interleukins / biosynthesis*
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Ionomycin / pharmacology
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Lymphocyte Activation*
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Membrane Glycoproteins / genetics
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Mice
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Perforin
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Pore Forming Cytotoxic Proteins
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T-Lymphocyte Subsets / immunology*
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T-Lymphocytes, Cytotoxic / immunology
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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CD4 Antigens
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CD8 Antigens
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Interleukin-2
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Interleukin-5
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Interleukins
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Membrane Glycoproteins
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Pore Forming Cytotoxic Proteins
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Perforin
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Interleukin-10
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Interleukin-4
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Ionomycin
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Tetradecanoylphorbol Acetate