Distinct responses of interleukin-6 and other laboratory parameters to treatment in a patient with Wegener's granulomatosis

H Nakahama; T Yokokawa; M Okada; M Miyazaki; N Imai; S Kubori; T Nakanishi; O Uyama; M Sugita

doi:10.2169/internalmedicine.32.189

Distinct responses of interleukin-6 and other laboratory parameters to treatment in a patient with Wegener's granulomatosis

Intern Med. 1993 Feb;32(2):189-92. doi: 10.2169/internalmedicine.32.189.

Authors

H Nakahama¹, T Yokokawa, M Okada, M Miyazaki, N Imai, S Kubori, T Nakanishi, O Uyama, M Sugita

Affiliation

¹ Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.

PMID: 8507933
DOI: 10.2169/internalmedicine.32.189

Abstract

We describe a patient with Wegener's granulomatosis in whom the serum levels of interleukin-6 (IL-6) and other laboratory parameters were monitored. The IL-6 and CRP levels, which were extremely high before treatment, declined rapidly with corticosteroid and cyclophosphamide. IgG, leukocyte count and platelet count declined more gradually. Thus, determination of the serum IL-6 level might be useful in diagnosing and monitoring Wegener's granulomatosis.

Publication types

Case Reports

MeSH terms

Biomarkers
C-Reactive Protein / analysis
Cyclophosphamide / therapeutic use
Enzyme-Linked Immunosorbent Assay
Granulomatosis with Polyangiitis / drug therapy
Granulomatosis with Polyangiitis / immunology*
Humans
Interleukin-6 / biosynthesis*
Male
Middle Aged
Prednisolone / therapeutic use

Substances

Biomarkers
Interleukin-6
Cyclophosphamide
C-Reactive Protein
Prednisolone