Abstract
When pentoxifylline was present during stimulation of human mononuclear leukocytes with Plasmodium falciparum exogenous antigens, an increase in interleukin-6 production was observed simultaneously with a reduction of tumor necrosis factor secretion. Similar results were obtained in murine macrophages stimulated with P. vinckei antigens. This indicates the independence of interleukin-6 and tumor necrosis factor secretion in response to malaria antigens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Protozoan / immunology*
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Humans
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Interleukin-6 / biosynthesis*
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Interleukin-6 / genetics
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / metabolism*
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Lipopolysaccharides / pharmacology
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Mice
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Mice, Inbred C57BL
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Pentoxifylline / pharmacology*
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Plasmodium / immunology*
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Plasmodium falciparum / immunology
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RNA, Messenger / analysis
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Antigens, Protozoan
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Interleukin-6
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Lipopolysaccharides
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RNA, Messenger
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Tumor Necrosis Factor-alpha
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Pentoxifylline