Benzothiazine and benzothiazepine derivatives: synthesis and preliminary biological evaluation

Farmaco. 1993 Feb;48(2):275-83.

Abstract

Several tricyclic benzothiazines and benzothiazepines have been synthesized by different intramolecular cyclization reactions. Their functionalization led to biologically active compounds. Some stereochemical aspects as well as biological responses have been outlined.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cyclization
  • Humans
  • Leukemia L1210 / drug therapy
  • Leukemia, Lymphoid / drug therapy
  • Mice
  • Molecular Conformation
  • Thiazepines / chemical synthesis*
  • Thiazepines / pharmacology
  • Thiazines / chemical synthesis*
  • Thiazines / pharmacology
  • Tumor Cells, Cultured

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Thiazepines
  • Thiazines