Abstract
Radioprotective and therapeutic effects of astazian and astazilide, the drugs of protozoan origin, were studied in comparison with known modifiers of biological reactions (bacterial polysaccharides, synthetic polypeptides) in combined radiation-thermal injuries (CRTI). The efficiency of drugs under examination was found to be time- and dose-dependent. Application of the drugs of protozoan nature 24 hours prior to or 1 hour following CRTI provided 30 to 50% survival of experimental animals for 30 days as compared to 4.5% in the group of untreated mice. Administration of the drugs 3-7 days following CRTI exerted no therapeutic effect.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Burns / drug therapy
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Burns / mortality
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Burns / prevention & control*
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Drug Evaluation, Preclinical
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Eukaryota*
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Fatty Acids / therapeutic use*
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Glucans / therapeutic use*
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Lipopolysaccharides / therapeutic use
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Luminescent Measurements
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Polysaccharides / therapeutic use*
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Prodigiozan / therapeutic use
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Pyrogens / therapeutic use
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Radiation Injuries, Experimental / drug therapy
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Radiation Injuries, Experimental / mortality
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Radiation Injuries, Experimental / prevention & control*
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Radiation-Protective Agents / therapeutic use*
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Time Factors
Substances
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Fatty Acids
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Glucans
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Lipopolysaccharides
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Polysaccharides
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Pyrogens
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Radiation-Protective Agents
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pyrogenal
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paramylon
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Prodigiozan
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astasilid