Abstract
Using the multilayer membrane system (MMS) the drug availability of four drugs from commercial topical formulations are determined. It was found that the availability differs when commercial formulations of beta-methasone-17-valerate, hydrocortisone, diclofenac-Na and clotrimazole were studied. It is shown that the drug availability for characterizing topical formulations has to be taken into account. The MMS applied in this study can be used for the determination of this parameter.
MeSH terms
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Administration, Topical
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacokinetics*
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Betamethasone Valerate / administration & dosage
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Betamethasone Valerate / pharmacokinetics
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Biological Availability
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Clotrimazole / administration & dosage
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Clotrimazole / pharmacokinetics
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Diclofenac / administration & dosage
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Diclofenac / pharmacokinetics
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Hydrocortisone / administration & dosage
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Hydrocortisone / pharmacokinetics
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Membranes, Artificial
Substances
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Anti-Inflammatory Agents
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Membranes, Artificial
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Diclofenac
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Betamethasone Valerate
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Clotrimazole
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Hydrocortisone