Synthesis and pharmacological activity of imidazo[2,1-b]benzothiazole acids

Farmaco. 1993 Jan;48(1):31-43.

Abstract

We have prepared twelve imidazo[2,1-b]benzothiazole carboxylic and acetic acids by reaction of substituted 2-aminobenzothiazoles with ethyl bromopyruvate and 4-chloroacetoacetate, respectively. The acids, obtained from esters by hydrolysis, were tested for their antiinflammatory, analgesic and ulcerogenic activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Female
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Imidazoles / toxicity
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Molecular Conformation
  • Pregnancy
  • Rats
  • Stomach Ulcer / chemically induced*
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology
  • Thiazoles / toxicity

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Imidazoles
  • Thiazoles