The purpose of this study was to investigate the effect of age and sex on craniomandibular disorders. A total of 195 subjects were examined, 148 women and 47 men. The range of age was 16 to 70 years. Clinical and anamnestic examination data established the ratio of women to men as 4:1. The prevalence of clicking, headache, teeth-clenching, hypomobility, difficulty in mastication, and neuromuscular symptoms was greater among young women than in other age and sex groups. There was a statistically significant correlation between severity of symptoms and age among women, and a relative decline by age in the prevalence of symptoms for both sexes. Finally, younger patients showed a greater prevalence of neuromuscular symptoms, whereas older patients had more peripheral symptoms.