Rate-responsive pacing allows patients with chronotropic incompetence to achieve more physiologic heart rate responses to exercise. One sensor currently being investigated uses impedance-derived measurements of changes in right ventricular stroke volume to alter the pacing rate. Correlation of pacemaker-derived measurements of stroke volume with an accepted method of stroke volume measurement has not been performed. The relative changes in impedance-derived stroke volume were compared in 10 patients with an impedance-based dual-chamber rate-responsive pacemaker (Precept DR, Cardiac Pacemakers, Inc.) with simultaneous Doppler echocardiographic measurements of right and left ventricular stroke volume. These comparisons were made during pacing at 2 heart rates (70 and 100 beats/min) and 3 AV intervals (150, 200 and 250 ms) while in a supine resting state, during lower body negative pressure to -30 mm Hg, and while performing 25% maximal handgrip. Pacemaker-derived stroke volume decreased by 7 to 11% and Doppler time-velocity integral measurements decreased by 14 to 19% in response to an increase in pacing rate (p = NS). There was also no significant difference by either technique in the mean stroke volume change when the atrioventricular interval was varied. Both techniques detected a decrease in stroke volume during lower body negative pressure, ranging from -7 to -20% by pacemaker, and -17 to -38% by Doppler. Overall, the pacemaker stroke volume measurements responded in an appropriate direction to each intervention, signaling the pacemaker's ability to detect directional change in stroke volume. The Precept DR may aid in the programming of parameters such as atrioventricular interval and heart rate by allowing for optimization of stroke volume in individual patients.