Synthesis and biological activity of bromolignans and cyclolignans

Arch Pharm (Weinheim). 1993 Jul;326(7):421-6. doi: 10.1002/ardp.19933260709.

Abstract

Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows anti-viral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase Inhibitors
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Folic Acid Antagonists
  • Glutathione Transferase / antagonists & inhibitors
  • Humans
  • Leukemia P388 / drug therapy
  • Lignans
  • Lignin / chemical synthesis*
  • Lignin / pharmacology
  • Mice
  • Mice, Inbred DBA
  • Neoplasms, Experimental / drug therapy

Substances

  • Adenosine Deaminase Inhibitors
  • Antineoplastic Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Folic Acid Antagonists
  • Lignans
  • Lignin
  • Glutathione Transferase