Abstract
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows anti-viral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Deaminase Inhibitors
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Folic Acid Antagonists
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Glutathione Transferase / antagonists & inhibitors
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Humans
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Leukemia P388 / drug therapy
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Lignans
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Lignin / chemical synthesis*
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Lignin / pharmacology
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Mice
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Mice, Inbred DBA
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Neoplasms, Experimental / drug therapy
Substances
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Adenosine Deaminase Inhibitors
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Antineoplastic Agents
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Antiviral Agents
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Enzyme Inhibitors
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Folic Acid Antagonists
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Lignans
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Lignin
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Glutathione Transferase