[Prostaglandin E1 bladder instillations for a patient with severe hemorrhagic cystitis after allogeneic bone marrow transplantation]

C Nakaseko; H Oh; K Kogure; A Ishii; H Ishii; T Ikegami; E Kawano; M Nishimura; Y Matsuura; S Morio

[Prostaglandin E1 bladder instillations for a patient with severe hemorrhagic cystitis after allogeneic bone marrow transplantation]

Rinsho Ketsueki. 1993 Jun;34(6):769-72.

[Article in Japanese]

Authors

C Nakaseko¹, H Oh, K Kogure, A Ishii, H Ishii, T Ikegami, E Kawano, M Nishimura, Y Matsuura, S Morio, et al.

Affiliation

¹ Second Department of Internal Medicine, Chiba University School of Medicine.

PMID: 8366582

Abstract

A 39-year-old female with AML (M2) underwent allogeneic bone marrow transplantation (BMT) on July 8th, 1991. The post transplantation course had been going well until day 85 post BMT, when severe hemorrhagic cystitis with right hydronephrosis and ureter stenosis developed. Adenovirus type 11 was isolated from the urine. She received instillations of prostaglandin E1 (PGE1) directly into the bladder after the appearance of clots in the urine. Complete resolution of hematuria was obtained by two courses of this treatment. PGE1 bladder instillations seem to be effective for the control of hematuria caused by severe hemorrhagic cystitis after BMT.

Publication types

Case Reports
English Abstract

MeSH terms

Adenovirus Infections, Human*
Adenoviruses, Human / isolation & purification
Administration, Intravesical
Adult
Alprostadil / administration & dosage*
Bone Marrow Transplantation*
Cystitis / drug therapy*
Cystitis / microbiology
Female
Hemorrhage / drug therapy*
Hemorrhage / microbiology
Humans
Leukemia, Myeloid, Acute / therapy*
Transplantation, Homologous

Substances

Alprostadil