The effect of 1,4-dihydropyridine and 1,4-dihydroindeno[1,2-b]pyridine derivatives on glutathione S-transferase activity in vitro

D Tirzite; G Tirzitis; B Vigante; G Duburs

doi:10.1016/0006-2952(93)90569-i

The effect of 1,4-dihydropyridine and 1,4-dihydroindeno[1,2-b]pyridine derivatives on glutathione S-transferase activity in vitro

Biochem Pharmacol. 1993 Aug 17;46(4):773-5. doi: 10.1016/0006-2952(93)90569-i.

Authors

D Tirzite¹, G Tirzitis, B Vigante, G Duburs

Affiliation

¹ Laboratory of Membrane Active Compounds of Latvian Institute of Organic Synthesis, Riga.

PMID: 8363652
DOI: 10.1016/0006-2952(93)90569-i

Abstract

The 1,4-dihydropyridine (1,4-DHP) and 1,4-dihydroindeno[1,2-b]pyridine (1,4-DHIP) derivatives were investigated as glutathione S-transferase (GT) inhibitors. The obtained results indicate that some of the 1,4-DHP's containing lipophylic and bulky substituents have inhibitory effects on GT in vitro. The derivatives of 1,4-DHIP are more pronounced inhibitors.

MeSH terms

Animals
Cattle
Dihydropyridines / pharmacology*
Glutathione Transferase / antagonists & inhibitors*
Liver / enzymology
Pyridines / pharmacology*

Substances

Dihydropyridines
Pyridines
1,4-dihydropyridine
Glutathione Transferase