Abstract
Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed phenotype with myeloid cytochemical markers, pre-B surface antigens and molecular markers of pro-B lymphocytes. They represent murine models for mixed phenotype (pro-pre-B-myeloid) leukemias.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Surface / analysis
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Female
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Immunophenotyping
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Leukemia, Experimental / genetics*
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Leukemia, Experimental / immunology
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Leukemia, Experimental / pathology
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Leukemia, Myeloid / genetics
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Leukemia, Myeloid / immunology
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Leukemia, Myeloid / pathology
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Leukemia, Radiation-Induced / genetics
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Leukemia, Radiation-Induced / immunology
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Leukemia, Radiation-Induced / pathology
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Male
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Mice
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Mice, Inbred Strains
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Phenotype
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Tumor Cells, Cultured / immunology
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Tumor Cells, Cultured / pathology