Is Tolosa-Hunt syndrome a limited form of Wegener's granulomatosis? Report of two cases with anti-neutrophil cytoplasmic antibodies

C Montecucco; R Caporali; C Pacchetti; M Turla

doi:10.1093/rheumatology/32.7.640

Is Tolosa-Hunt syndrome a limited form of Wegener's granulomatosis? Report of two cases with anti-neutrophil cytoplasmic antibodies

Br J Rheumatol. 1993 Jul;32(7):640-1. doi: 10.1093/rheumatology/32.7.640.

Authors

C Montecucco¹, R Caporali, C Pacchetti, M Turla

Affiliation

¹ Istituto di Patologia Medica, IRCCS S. Matteo University Hospital, Pavia, Italy.

PMID: 8339143
DOI: 10.1093/rheumatology/32.7.640

Abstract

Two patients with recurrent painful ophthalmoplegia due to granulomatous involvement of the intracavernous sinus (Tolosa-Hunt syndrome) had circulating anti-neutrophil cytoplasmic antibodies with a granular cytoplasmic immunofluorescence pattern during a flare-up of the disease. The presence of these antibodies suggests that Tolosa-Hunt syndrome might be regarded as a localized form of Wegener's granulomatosis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies / analysis*
Autoantibodies / immunology
Female
Fluorescent Antibody Technique
Granulomatosis with Polyangiitis / complications
Granulomatosis with Polyangiitis / diagnosis
Granulomatosis with Polyangiitis / immunology*
Humans
Middle Aged
Ophthalmoplegia / diagnosis
Ophthalmoplegia / etiology
Ophthalmoplegia / immunology*

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies