It was reported that experimental study on the action of EDTA-Liposome to remove mercury from the mice given methylmercury chloride showed that elimination of methylmercury chloride from brain, testicle, liver, kidney and blood of mice treated by EDTA-Liposome was more significant than that of mice treated by EDTA alone. Mercury level in feces of EDTA-Liposome treated group increased significantly (P < 0.001). The advantages of treatment with EDTA-Liposome were discussed. Applying EDTA-Liposome is an efficient method in therapy of metal poisoning.