A 55-year-old woman underwent bronchoscopic evaluation for hemoptysis. A small polypoid endotracheal nodule was discovered approximately 2.0 cm distal to the left true vocal cord. The lesion was sampled with a cytologic brush. Epithelioid histiocytes and numerous giant cells with asteroid bodies were seen, and there was abundant intracellular refractile material of irregular shape. Review of the medical history revealed that the patient had undergone Teflon injection of a paralyzed left true vocal cord. A diagnosis of Teflon granuloma was made.