Mechanism of thymidylate synthase inhibition by N4-hydroxy-(N4-hydroxy-5- fluoro)-dCMP in view of the structure and conformation of N4-hydroxy-(N4-hydroxy-5-fluoro)-cytosine calculated by the AB initio quantum mechanical methods

Adv Exp Med Biol. 1993:338:621-4. doi: 10.1007/978-1-4615-2960-6_128.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calorimetry
  • Deoxycytidine Monophosphate / analogs & derivatives*
  • Deoxycytidine Monophosphate / chemistry
  • Deoxycytidine Monophosphate / pharmacology
  • Flucytosine / analogs & derivatives*
  • Flucytosine / chemistry
  • Isomerism
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Quantum Theory
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Deoxycytidine Monophosphate
  • N(4)-hydroxy-5-fluorodeoxycytidine monophosphate
  • N(4)-hydroxy-5-fluorocytosine
  • Flucytosine
  • Thymidylate Synthase