[Activity of the xenobiotic metabolism system under the effect of chemical pollution of the atmosphere and water]

Abstract

Functional state of the system involved in biotransformation of xenobiotics in animal liver tissue was studied under conditions of combined chemical contamination of atmospheric air and water simulating the typical real loading. The model loading studied caused in some cases an induction of the microsomal monooxygenases without activation of UDP-glucuronosyl transferase, but simultaneously with accumulation of malonic dialdehyde; this suggests that metabolic alterations observed may be involved in development of pathology.