We describe 2 rare cases of adult type squamous papillomatosis of larynx with spread to the trachea and bronchial tree that occurred at the age of 72 and 42, respectively. They were treated with laser therapy for laryngeal and tracheal lesions; the first case also received surgical resection. However, due to the extent of papilloma involvement, the outcomes were completely different between both. The first patient had all lesions successfully removed by combined surgical resection and laser photoresection, and the patient remained asymptomatic up to 7 years after the operation. The second patient, however, had been bothered by recurrent tumors with associated repeated secondary infections, despite treatment, for 6 years and 3 months before his death.