Anaesthetic phencyclidine, blocker of the ATP-sensitive potassium channels

Abstract

The double sucrose gap and patch-clamp studies revealed that phencyclidine blocked the ATP-sensitive K+ channel in isolated cardiac cells (half-maximal inhibition at approximately 20 microM; Hill coefficient approximately 1). 10 microM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.