Cytomegalovirus infection in two infants with congenital or neonatal solid tumors

G Nigro; U Bartmann; E Properzi; A Torre; A Schiavetti; M Castello

doi:10.3109/08880019309029515

Cytomegalovirus infection in two infants with congenital or neonatal solid tumors

Pediatr Hematol Oncol. 1993 Oct-Dec;10(4):351-5. doi: 10.3109/08880019309029515.

Authors

G Nigro¹, U Bartmann, E Properzi, A Torre, A Schiavetti, M Castello

Affiliation

¹ Pediatric Institute of La Sapienza University, Rome, Italy.

PMID: 8292521
DOI: 10.3109/08880019309029515

Abstract

Two infants with fibrosarcoma and rhabdomyosarcoma diagnosed prenatally and at 2 months of age, respectively, and cytomegalovirus (CMV) infection are reported. Concomitant CMV infection was revealed by positive urine culture and/or CMV DNA, and CMV-specific IgM, IgA, and complement-fixing antibodies. The patients, showing very low levels of immune T cells, died at 3 and 8 months of age, respectively. A pathogenic role for CMV in the progression of the tumors is suggested.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus Infections / complications
Cytomegalovirus Infections / congenital*
Cytomegalovirus Infections / diagnosis
Fibrosarcoma / complications
Fibrosarcoma / congenital*
Humans
Infant
Infant, Newborn
Male
Rhabdomyosarcoma / complications
Rhabdomyosarcoma / congenital*