Function of a human cyclin gene as an oncogene

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):709-13. doi: 10.1073/pnas.91.2.709.

Abstract

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenovirus E1A Proteins / genetics
  • Alleles
  • Amino Acid Sequence
  • Animals
  • Cell Line, Transformed
  • Cell Transformation, Neoplastic / genetics
  • Cells, Cultured
  • Cyclin D1
  • Cyclins / genetics*
  • Defective Viruses / genetics
  • Genes, Viral
  • Genetic Complementation Test
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Oncogene Proteins / genetics*
  • Oncogenes*
  • Rats
  • Transfection

Substances

  • Adenovirus E1A Proteins
  • Cyclins
  • Oncogene Proteins
  • Cyclin D1